Check Carefully (1)pentobarbital will minimize the extent or outcome of hydrocodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Warning when discontinuing CYP3A4 inducers that are coadministered with hydrocodone; plasma concentrations of hydrocodone might increase and can result in possibly fatal respiratory depressionSerious - Use Substitute (1)hydrocodone, pentobarbital.
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pentobarbital will lower the level or effect of eltrombopag by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Monitor.
pentobarbital will lessen the level or effect of methylprednisolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will reduce the extent or influence of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
Exercising caution when administered to patients with acute or Continual discomfort; could end in paradoxical pleasure or critical indications may very well be masked
pentobarbital will lessen the level or effect of pioglitazone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.
pentobarbital will lower the extent or impact of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lessen the level or outcome of etoposide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Untimely infants are especially at risk of the depressant outcomes of barbiturates; if barbiturates are utilized for the duration of labor and shipping, resuscitation gear need to be offered
Cessation of benzodiazepines or other CNS depressants is chosen in most cases. In some instances, checking at a higher volume of take care of tapering CNS depressants can be proper. In Other individuals, little by little tapering a patient off of the prescribed benzodiazepine or other CNS depressant or reducing to the lowest productive dose may very well be proper.
pentobarbital will minimize the level or influence of quinidine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will minimize Nembutal the extent or effect of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
benzhydrocodone/acetaminophen and pentobarbital both equally raise sedation. Prevent or Use Alternate Drug. Restrict use to people for whom choice cure selections are inadequate